The content of CD4 + increased from 250 to 800 and remained at that level (Alonso K., Pontiggia P. Inhibition of HIV replication and augmentation of cellular cytotoxic response following systemic hyperthermia Abstr. 88th Ann. Sci. Assam. South Med. Assoc.Orlando, FLA, Nov. 2-6, 1994 South Med. J -1994, 87, # 9, p.131)
After hyperthermic treatment of HIV, found the reduction in viral load in patients, increasing their activity CD8 cytotoxic T-lymphocytes and natural killer cells. Increased the survival time of patients (24 out of 31, with the expected 6) for a period of 2 years discussed a mechanism of positive impact OUG.
Italy, clinic Clinica di Cura Citta, Pavia.
Studied the safety and effectiveness of double hyperthermia (with an interval of 4 days) in 30 patients with AIDS (not receiving protease inhibitors), randomized to:
1) Control group without treatment
2) group, which used hyperthermia low 40 ° C for 1 hour and repeat 96 hours later, and
3) group, which used hyperthermia high 42 ° C for 1 hour, repeating 96 hours later.
In a one-year observation after hyperthermia, there were positive therapeutic effects of treatment on the frequency of complications of AIDS, and the Index Karnovsky and maintaining body weight. However, the effect of treatment on the levels of HIV RNA and CD4 + was transitory. Two consecutive hyperthermia procedures were the same applied to the 4 patients receiving protease inhibitors / tri therapy. These patients noted improvements in HIV RNA and CD4 + and the good general condition. (Extracorporeal whole body, hyperthermia treatments for HIV infection and AIDS, (Ash, Steinhart, Curfman, Gingrich, Sapir, Ash, Fausset, and Yatvin1997)).
These studies indicate that the clinical application of hyperthermia can reduce viral load, but the available temperature range of 41-42 ° C is not enough to express the effect on the level of viraemia and the complexity and side effects extracorporal techniques further restrict the use of CG in HIV-infected.
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