About one percent of people infected with human immunodeficiency virus, the so-called elite controllers, even in the absence of treatment is not going to symptoms of AIDS.
Virologist and immunologist (Philip Mwimanzi) from Simon Fraser University (Vancouver, Canada) and his colleagues compared the virus isolated in 45 elite controllers and 48 patients in whom the disease progresses in a standard way. It was found that the protein Nef (Negative Regulatory Factor), which plays an important role in the development of HIV, the virus isolated from elite controllers, practically not functioning. Compared to a "normal" such Nef can not enter cells and replicate. In addition, the "elite" Nef can inhibit the expression of proteins on the surface of antigen-presenting cells. All this allows the immune system to control the virus, according to the study authors.
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